(E) Frequency and number of CD69 + Trm cells in the liver 30ĭays p.i. (D) Frequency of CD69 + memory OT-I cell subsets in the liverĦ2 days p.i. Circulating cells were identified by i.v. +) memory OT-I cell subsets in the lung 60 days p.i. (A-C) Frequency and number of resident (i.v. Our work demonstrates that developmental plasticity of KLRG1 + effector CD8 + T cells is important in promoting functionally versatile memory cells and long-term protective immunity.īach2 CD8 T cell CX(3)CR1 cancer fate mapping inflammation influenza memory plasticity tissue-resident.Ĭopyright © 2018 Elsevier Inc. "ExKLRG1" memory cells retained high cytotoxic and proliferative capacity distinct from other populations, which contributed to effective anti-influenza and anti-tumor immunity. Using genetic fate mapping analysis of highly cytotoxic KLRG1 + effector CD8 + T cells, we demonstrated that KLRG1 + cells receiving intermediate amounts of activating and inflammatory signals downregulated KLRG1 during the contraction phase in a Bach2-dependent manner and differentiated into all memory T cell linages, including CX 3CR1 int peripheral memory cells and tissue-resident memory cells. However, whether plasticity during effector-to-memory CD8 + T cell differentiation affects memory lineage specification and functional versatility remains unclear. Electronic address: immunity against pathogens depends on the efficient generation of functionally diverse effector and memory T lymphocytes. Electronic address: 10 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. 9 Laboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan Graduate School of Medical Life Science, Yokohama City University, Yokohama, Kanagawa 230-0045, Japan.8 Department of Pathology, Yale University School of Medicine, New Haven, CT 06511, USA Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA Applied Mathematics Program, Yale University, New Haven, CT 06511, USA. ![]() 7 Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.6 Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.5 Laboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.4 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA Department of Pathology, Yale University School of Medicine, New Haven, CT 06511, USA Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.Electronic address: 3 Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan. 2 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA Laboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan. ![]()
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